Status:
RECRUITING
A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer
Lead Sponsor:
Compugen Ltd
Conditions:
Ovarian Cancer
Ovarian Cancer Recurrent
Eligibility:
FEMALE
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The goal of this clinical trial is to learn if the experimental antibody COM701 delays the progression of ovarian cancer in participants with Relapsed Platinum Sensitive Ovarian Cancer. It will also l...
Detailed Description
Trial CPG-01-201 is an adaptive-platform trial comprised of multiple sub-studies. Sub-study 1 will be a parallel group, double-blind, randomized placebo-controlled trial in which participants will be...
Eligibility Criteria
Inclusion
- Has relapsed platinum sensitive epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer
- Has completed at least 2 previous courses (i.e. lines) of platinum-containing therapy
- For the last chemotherapy course prior to being randomized into the study, must have had a minimum of 4 cycles of a platinum containing regimen and achieved a partial or complete tumor response.
- Has received prior maintenance therapy with bevacizumab or a PARP inhibitor if eligible and is not a candidate for, or has declined in writing, bevacizumab or PARP inhibitor therapy.
- Have recovered from toxicities of prior chemotherapy or other therapy (to grade 1 or less, except for alopecia and neuropathy recovered to a ≤grade 2).
Exclusion
- Has had 4 or more lines of cytotoxic chemotherapy in total
- Is being treated with immunosuppressive doses of systemic medications, such as steroids within 2 weeks before study drug administration
- Has had prior treatment with PD-1, PD-L1, anti-PVRIG, TIGIT or any other check point inhibitors
- Presence of radiographic or biopsy proven liver metastases at the beginning or completion of current line of platinum-based chemotherapy.
- Drainage of ascites during last 2 cycles of last chemotherapy or any time after completion of the last chemotherapy regimen.
- Bowel obstruction in the 6 weeks prior to randomization.
- Have known active central nervous system metastases and/or carcinomatous meningitis / leptomeningeal carcinomatosis.
- Has active hepatitis B virus (HBV) or hepatitis C virus (HCV), or subjects with human immunodeficiency virus (HIV).
- Has active and clinically relevant bacterial, fungal, or viral infection that is not controlled or requires systemic antibiotics, antifungals, or antivirals, respectively.
- Has received a live viral vaccine within 30 days of planned start of study treatment or requiring a live vaccine during the study.
- Has a history of severe allergic, anaphylactic, or other hypersensitivity reactions to a human or humanized monoclonal antibody (mAb) or allergy to any excipients in the investigational products.
- Has any serious or unstable concomitant systemic disorder
- Has any other condition that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the opinion of the investigator, would make the subject inappropriate for entry into the study.
- Is currently participating in or have participated in a clinical study and received an investigational agent or used an investigational device within 4 weeks prior to the first dose of study treatment.
- Is pregnant or breastfeeding or planning to become pregnant during the period of the study.
Key Trial Info
Start Date :
July 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06888921
Start Date
July 21 2025
End Date
March 1 2027
Last Update
November 19 2025
Active Locations (22)
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1
The University of Chicago Medical Center
Chicago, Illinois, United States, 60637
2
Northwestern Memorial Hospital
Warrenville, Illinois, United States, 60555
3
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
4
Corewell Health
Grand Rapids, Michigan, United States, 49503