Status:
RECRUITING
Effect of Daily Mixed Spice Consumption on Memory Function
Lead Sponsor:
University of California, Los Angeles
Conditions:
Memory
Cognitive Function
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function. Recent research has indicated t...
Eligibility Criteria
Inclusion
- Participants are required to have clinical histories consistent with normal aging or mild cognitive impairment (MCI).
- Age 50 to 80 years.
- Adequate visual acuity and hearing to allow neuropsychological testing.
- Screening laboratory tests without significant abnormalities that might interfere with the study.
- \-
Exclusion
- Diagnosis of probable Alzheimer's disease or any other dementia (e.g. vascular, Lewy body, frontotemporal)
- Evidence of other neurological or physical illness that can produce cognitive deterioration. Determination of dementia will be based on the clinical evaluation including assessment of functional abilities, and cognitive screening (using the Mini Mental State Examination
- Evidence of Parkinson's disease as determined by the motor examination (items 18-31) of the Unified Parkinson's Disease Rating Scale \[38\].
- Uncontrolled hypertension (systolic blood pressure (BP) \> 170 or diastolic BP \> 100).
- Consume spices regularly \> 5g day
- Allergy or sensitivity to spices. Subjects will be excluded if there is a prior history of such sensitivity. Since these foods are commonly eaten and allergies are rare, subjects should be aware of this sensitivity prior to entering the study. To determine this, a positive history of spices ingestion without incident will be requested. In addition, any subject with a history of allergy or anaphylaxis of any kind will be excluded.
- Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria (APA, 2000).
- Current diagnosis or alcoholism or substance addiction.
- Eating a high fiber/polyphenol diet or taking any medication or dietary supplement which interfere with the absorption of polyphenols.
- Frequently using prebiotics, probiotics, yogurt, and/or any fiber supplements
Key Trial Info
Start Date :
February 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 21 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06889961
Start Date
February 21 2025
End Date
February 21 2027
Last Update
March 21 2025
Active Locations (1)
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1
UCLA Center for Human Nutrition
Los Angeles, California, United States, 90024