Status:
RECRUITING
Observation on the Correlation Between Serum/Fecal Isoflavones, Abundance of TMA-producing Bacteria and Serum TMAO in Hyperlipidemia and Healthy Subjects
Lead Sponsor:
Zhujiang Hospital
Conditions:
Hyperlipidemia
Eligibility:
All Genders
18-70 years
Brief Summary
Previous studies have shown that trimethylamine N-oxide (TMAO), a gut microbiota-related metabolite, plays a significant role in the development and progression of cardiovascular disease (CVD). How to...
Eligibility Criteria
Inclusion
- Hyperlipidemia inclusion criteria:
- 18-70 years old；
- patients diagnosed with hyperlipidemia；
- Healthy people inclusion criteria:
- 18-70 years old；
- male weight ≥50.0kg, female weight ≥45.0kg; body mass index (BMI) within the range of 19.0-26.0 kg/m2 (including critical values);
- volunteers have no history of chronic diseases or serious diseases such as cardiovascular, liver, kidney, respiratory, blood and lymphatic, endocrine, immune, mental, neuromuscular, gastrointestinal system within three years, and are in good overall health.
Exclusion
- Consuming dietary supplements (ω-3 fatty acids, probiotics, prebiotics, plant stanols/sterols) 1 month before the study;
- Using antibiotics, antidiarrheal drugs, statins, fibrates and other drugs within 2 months before the study;
- Drinking alcohol (\> 2 cups per day);
- Hyperlipidemia patients with inflammatory bowel disease or irritable bowel syndrome and healthy people.
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06890780
Start Date
January 1 2023
End Date
December 31 2025
Last Update
March 24 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 0086510282