Status:
COMPLETED
Gut Dysbiosis in Spinal Cord Injury Rehabilitation
Lead Sponsor:
Centro Academico Clínico Egas Moniz Health Alliance
Collaborating Sponsors:
Centro de Reabilitacao do Norte
Unidade Local de Saude de Gaia e Espinho EPE
Conditions:
Spinal Cord Injury
Gut Dysbiosis
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this study is to investigate the role of gut microbiota, and related immune biomarkers and metabolites, in the functional recovery of spinal cord injury patients during the subacute phase....
Detailed Description
Background: Spinal cord injury (SCI) is a devastating condition with no effective cure. Gut dysbiosis and chronic immune dysfunction are common complications that may hinder recovery. This study aims...
Eligibility Criteria
Inclusion
- Adults (≥18 years) with traumatic spinal cord injury.
- Injury occurred less than 6 months ago (subacute phase).
- Any neurological level of injury (AIS A-D).
Exclusion
- Use of probiotics or immunomodulatory drugs in the last month.
- Major gastrointestinal surgery in the last 5 years.
- Active gastrointestinal diseases or other CNS diseases.
Key Trial Info
Start Date :
May 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 16 2023
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT06892106
Start Date
May 1 2021
End Date
October 16 2023
Last Update
March 24 2025
Active Locations (1)
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1
Centro de Reabilitação do Norte (CRN) / Unidade Local de Saúde Gaia e Espinho (ULSGE)
Vila Nova de Gaia, Porto District, Portugal, 4405 - 565 Vila Nova de Gaia