Status:
ENROLLING_BY_INVITATION
Clinical Study of Pediatric Acute Liver Failure
Lead Sponsor:
Fansen Zeng
Conditions:
Acute Liver Failure
Eligibility:
All Genders
1-18 years
Brief Summary
The goal of this observational study is to understand the etiology, prognosis and influencing factors of acute liver failure in children, evaluate the predictive value of children's SOFA score, PELD s...
Detailed Description
PALF is a seriously life-threatening acute disease with a rapid onset, rapid progression and high mortality rate. Especially under the influence of multiple organ dysfunction syndrome (MODS) or other ...
Eligibility Criteria
Inclusion
- （1) The age is less than 18 years old; (2) Acute onset (≤8 weeks), no liver disease basis in the past; (3) Biochemical evidence of severe liver injury ; (4) Coagulation dysfunction that cannot be corrected by vitamin K: prothrombin time (PT) ≥15s or international standardized ratio (INR) ≥1.5, and accompanied by hepatic encephalopathy at the same time; or meet any of PT≥20s, INR≥2.0, may not be accompanied by hepatic encephalopathy; (5) Provide complete clinical data and treatment records. (6) Agree to participate in this study and obtain informed consent.
Exclusion
- (1) Multiple organ failure caused by non-hepatic diseases; (2) Missing data or incomplete follow-up information.
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Key Trial Info
Start Date :
September 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT06893042
Start Date
September 1 2024
End Date
August 1 2026
Last Update
March 25 2025
Active Locations (1)
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1
Guangzhou Women's and Children's Medical Center
Guangzhou, Guangdong, China, 510000