Status:
RECRUITING
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
Lead Sponsor:
Medical University of Graz
Conditions:
Chronic Pain
Central Sensitisation
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid. 5-HT...
Detailed Description
Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid. 5-HTP can cross the blood-brain barrier and is converted to serotonin. Low serotonin lev...
Eligibility Criteria
Inclusion
- Exclusion Criteria:
- pregnancy or breastfeeding.
- renal or hepatic insufficiency
- neurological/dermatological/cardiovascular diseases
- chronic pain and/or use of analgesics
- intake of antidepressants
- intake of MAO inhibitors
- intake of sleep medication
- intake of St. John's wort
- allergy to Griffonia simplicifolia
Exclusion
Key Trial Info
Start Date :
September 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 20 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06893822
Start Date
September 12 2025
End Date
December 20 2025
Last Update
June 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical University of Graz
Graz, Austria, 8010