Status:
NOT_YET_RECRUITING
Oral Tranexamic Acid After Total Knee Arthroplasty
Lead Sponsor:
Rush University Medical Center
Conditions:
Total Knee Arthroplasty
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA). The study will assess pain, function, and range...
Detailed Description
OBJECTIVES: Purpose: This is a prospective, double-blinded, randomized control study to evaluate the efficacy and role of oral Tranexamic acid in total knee arthroplasty by assessing pain, function,...
Eligibility Criteria
Inclusion
- Any patient undergoing primary TKA at Rush main hospital or participating ASC
- Willingness to undergo randomization to take medication potentially up to 7 days post op.
- Willing to answer daily questions on pain, functionality and opioid consumption
Exclusion
- History of venous thromboembolism, MI, or stroke in the past year
- Patients on any chronic anticoagulation medications besides Aspirin
- Patients with Cancer
- Patients with end stage renal disease that are on dialysis
- Drug allergy to TXA
- Taking oral birth control
- Unable to provide consent
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
351 Patients enrolled
Trial Details
Trial ID
NCT06894719
Start Date
January 1 2026
End Date
September 1 2026
Last Update
November 14 2025
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