Status:
RECRUITING
Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC
Lead Sponsor:
The First Affiliated Hospital of Zhengzhou University
Conditions:
Non-Small Cell Lung Cancer
Chemotherapy
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Chemotherapeutic agents exert significant immunomodulatory effects by influencing tumor-infiltrating immune cells. However, the sequence and combination of chemotherapy regimens differentially modulat...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed diagnosis of lung squamous cell carcinoma or adenocarcinoma.
- Documented disease progression following first-line chemotherapy or chemo-immunotherapy.
- Age ≥18 years at the time of enrollment.
Exclusion
- Patients with small cell lung cancer or other histological subtypes of lung cancer.
- Patients lost to follow-up, who discontinued treatment, or died within one year of diagnosis.
- Pregnant or lactating women
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06896422
Start Date
June 1 2025
End Date
December 31 2027
Last Update
August 7 2025
Active Locations (1)
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1
the First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052