Status:
RECRUITING
Esketamine Combined Pregabalin and Duloxetine for Postherpetic Neuralgia
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
Beijing Xiaotangshan Hospital
The First Hospital of Fangshan District,Beijing
Conditions:
Postherpetic Neuralgia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To assess the 1-week effects and safety of esketamine in combination with pregabalin and duloxetine to relieve pain in patients with postherpetic Neuralgia(PHN).
Detailed Description
The investigators aim to investigate whether or not esketamine combined with pregabalin and duloxetine to relieve pain in patients with PHN, and seek a rapid, effective and safe treatment for refracto...
Eligibility Criteria
Inclusion
- Ages more than 18 years;
- Pain present for more than 3 months after healing of a herpes zoster skin rash;
- Has an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0= no pain, 10= worst possible pain)；
- Failed to respond to or tolerate the effective dose of pregabalin monotherapy.
Exclusion
- Obstructive sleep apnoea syndrome;
- Those who receive interventional treatments;
- A history of systemic immune diseases, organ transplantation, or cancers;
- A history of severe cardiopulmonary, hepatic or renal dysfunction;
- A history of schizophrenia, epilepsy, or myasthenia gravis, delirium;
- Currently using monoamine oxidase inhibitors (MAOIs);
- Having untreated angle-closure glaucoma;
- Those suffering from increased intracranial pressure；
- Comorbid hyperthyroidism or phaeochromocytoma;
- Suspected or confirmed history of drug abuse;
- Having contraindications to esketamine, pregabaline or duloxetine;
- Communication difficulties;
- Women who are preparing for pregnancy, in the pregnancy or lactation period.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06896994
Start Date
April 1 2025
End Date
May 1 2026
Last Update
April 27 2025
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070