Status:
ACTIVE_NOT_RECRUITING
High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis
Lead Sponsor:
Ruijin Hospital
Collaborating Sponsors:
Shanghai Municipal Science and Technology Commission
Conditions:
Severe Acute Pancreatitis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study is a prospective, randomized, double-blinded, parallel-controlled, multi-central clinical trial for patients with severe acute pancreatitis (SAP). Patients with SAP in the early stage (with...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Time from onset of illness to enrollment is less than 7 days
- Meet the 2012 Atlanta Guidelines SAP diagnostic criteria
Exclusion
- SAP caused by tumors or ERCP
- Pregnant or breastfeeding
- Allergic to vitamin C
- Use of other experimental drugs within the timeframe of this study
- Chronic organs failure such as heart, liver, lung, or kidney before admission, with specific indicators being (chronic cardiovascular dysfunction requiring long-term mechanical hemodynamic support or inotropic drug support; chronic obstructive pulmonary disease requiring home oxygen therapy; chronic liver dysfunction at Child-Pugh Class C; chronic kidney disease with an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m² or serum creatinine greater than 150 μmol/L)
- Immunosuppressed state, including malignant tumors, post-transplant status, long-term use of immunosuppressor (for at least 1 month before enrollment), AIDS, etc.
- The patient and family are unwilling to sign the informed consent form
- Body weight greater than 100kg
- Urinary system stones
Key Trial Info
Start Date :
March 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
388 Patients enrolled
Trial Details
Trial ID
NCT06897384
Start Date
March 1 2025
End Date
December 31 2027
Last Update
March 26 2025
Active Locations (1)
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1
Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital
Shanghai, Shanghai Municipality, China