Status:
NOT_YET_RECRUITING
Efficacy of Cerebellar Transcranial Magnetic Stimulation to Treat Hereditary Spinocerebellar Ataxias
Lead Sponsor:
Xijing Hospital
Conditions:
Spinocerebellar Ataxias
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Spinocerebellar ataxia (SCA) is a type of autosomal dominant ataxia and there is currently no effective treatment. The goal of this clinical trial is to learn the efficacy of navigated iTBS (Intermitt...
Detailed Description
1. Gait analysis, electroencephalogram (EEG), functional magnetic resonance (fMRI) and a series of clinic scales were used to further observe the therapeutic effect and reveal the possible mechanism o...
Eligibility Criteria
Inclusion
- SCA1/2/3 patients confirmed by genetic testing
- aged 18-65 years
- presence of ataxia with a score3-20 on the Scale for the Assessment and Rating of Ataxia (SARA) and a score\<60 on the International Cooperative Ataxia Rating Scale (ICARS)
- Signed informed consent by patients or their family members
Exclusion
- Patients with serious medical conditions (such as kidney failure, liver disease) and uncontrolled high blood pressure or diabetes
- Patients with severe cognitive and behavioral disorders or mental illness
- Pregnant and lactating patients; Use other ongoing clinical medications, except for neuroprotective agents such as coenzyme Q10, butylphthalein, or cyticholine; If patients are taking valproate, riluzole and other drugs but they and their guardians have a strong desire for treatment, they can be evaluated again after washout.
- History of stroke, encephalitis and epilepsy
- Pacemakers, electronic devices and intracranial metal objects.
Key Trial Info
Start Date :
March 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06898645
Start Date
March 20 2025
End Date
December 31 2027
Last Update
March 27 2025
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