Status:
RECRUITING
Comparative of Plasma Proteomics & Metabolomics in Coronary Artery Disease: Obstructive,Non-Obstructive, & No Lesions
Lead Sponsor:
University of Sao Paulo General Hospital
Conditions:
Coronary Arterial Disease (CAD)
Eligibility:
All Genders
50-80 years
Brief Summary
The presence and clinical evolution of coronary atherosclerosis depend on various classic risk factors and biomarkers. However, the search for more specific markers is necessary, especially for indivi...
Detailed Description
INTRODUCTION The presence and clinical evolution of coronary atherosclerosis depend on several classic risk factors, such as age, sex, arterial hypertension, dyslipidemia, diabetes, smoking, family hi...
Eligibility Criteria
Inclusion
- Group I: Patients without manifest atherosclerotic disease (no history of angina, previous myocardial infarction, prior revascularization, cerebrovascular disease, or peripheral vascular disease).
- Group II: Patients with non-obstructive coronary lesions (\< 50%) detected on coronary computed tomography angiography (CCTA) or invasive coronary angiography (ICA).
- Group III: Patients with obstructive coronary lesions (≥ 50%) detected on CCTA or ICA.
Exclusion
- Patients who refuse to sign the informed consent form (ICF);
- Individuals with non-atherosclerotic heart disease (such as valvular diseases, cardiomyopathies, or congenital heart diseases);
- Severe nephropathy (creatinine clearance \< 30 mL/min/1.73 m² body surface area);
- Malignant neoplasms or other chronic diseases with poor prognosis;
- Patients with acute coronary syndromes within the last 90 days;
- Active smoking.
Key Trial Info
Start Date :
August 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT06900270
Start Date
August 1 2024
End Date
February 1 2026
Last Update
March 28 2025
Active Locations (1)
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1
Instituto do Coração InCor, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo
São Paulo, São Paulo, Brazil, 05403-000