Status:
RECRUITING
Stroke Volume Variation Versus Central Venous Pressure Guidance for Reducing Perioperative Blood Loss During Open Liver Resection
Lead Sponsor:
Warangkana Lapisatepun
Collaborating Sponsors:
Chiang Mai University
Conditions:
Liver Tumor; Surgery
Primary Liver Tumor, Metastatic Liver
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
Liver resection is a major surgery that can be associated with significant intraoperative blood loss and blood transfusion. Among high-volume centers, median intraoperative blood loss ranges between 3...
Detailed Description
Bleeding is the most common and concerning complication in liver resection because it affects overall complications. Nowadays, there are numerous surgical and anesthetic techniques to decrease blood l...
Eligibility Criteria
Inclusion
- All genders, age 18 to 70 years old
- American Society of Anesthesiologists (ASA) physical status classification of I-III
- The patients who scheduled in elective open liver resection and diagnosed Hepatocellular Carcinoma, Cholangiocarcinoma, Liver metastasis, and Benign malignant tumor.
Exclusion
- Pregnancy
- Active cardiac conditions (unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease, active coronary artery disease within 6 months prior surgery)
- History of significant cerebrovascular disease (Patients with clinically significant stroke/CVA within 6 months prior surgery, severe carotid stenosis)
- Renal dysfunction (GFR \< 60 ml/min/1.73 m²)
- Abnormal coagulation parameters (INR \>1.5 not on warfarin and/or platelet count \<100,000)
- Preoperative autologous blood donation
- Tumor size \> 10 cm.
- Previous liver resection
- Withdrawal criteria:
- Unresectable tumor
- Persistent intraoperative hypotension that cannot be corrected with vasopressors.
- Cardiac arrest during operation
- Low central venous pressure (CVP \< 5 mmHg) or high stroke volume variation (SVV \>13%) cannot be achieved before and during liver parenchymal transection.
Key Trial Info
Start Date :
November 25 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2028
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT06905015
Start Date
November 25 2024
End Date
June 30 2028
Last Update
April 1 2025
Active Locations (1)
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1
Department of Anesthesiology, Faculty of Medicine, Chiang Mai University
Chiang Mai, Chiangmai, Thailand, 50200