Status:
RECRUITING
Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma
Lead Sponsor:
Medical University of South Carolina
Conditions:
Soft Tissue Sarcoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this research study is to preserve healthy tissue around the cancer on the arm(s) and/or leg(s) using Hypofractionated radiotherapy, while treating the cancer and preventing it from spr...
Detailed Description
This study is for subjects that have been diagnosed with cancer in their arm, leg, or trunk (the part of the body that involves the chest, abdomen, and pelvis). The purpose of this research study is t...
Eligibility Criteria
Inclusion
- Willingness and provision of informed consent via signed and dated copy.
- Histologically confirmed STS of extremity or trunk.
- Male or female, aged greater than or equal to 18 years old
- ECOG performance status 0-3
- Meets screening criteria for receipt of radiotherapy.
- Deemed eligible for wide local excision.
- Patient and/or physician identified possible barriers to receiving a 5-week course of conventionally fractionated preoperative radiotherapy. Potential barriers include but are not limited to concern for local progression that could precluded or complicate limb sparing surgery, concern for distant progression that could result in patient being non-operative, financial and/or physical burden of travel for daily treatments, financial burden of time away from work or caregiving.
Exclusion
- Distant metastatic disease
- Prior radiation therapy in the proposed treatment area
- Simultaneous treatment of another malignancy
- Women who are pregnant or plan to become pregnant during the period of radiation therapy
- Planned concurrent administration of chemotherapy and radiation therapy
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06905132
Start Date
April 1 2025
End Date
March 31 2027
Last Update
April 18 2025
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29401