Status:
RECRUITING
Molecular-Based Selection of Patients with Head and Neck Squamous Cell Carcinoma: Biomarker Analysis
Lead Sponsor:
National Cancer Institute, Naples
Conditions:
Head and Neck Squamous Cell Carcinoma
Locally Advanced Stage
Eligibility:
All Genders
18+ years
Brief Summary
This is an observational, prospective study enrolling patients who meet the inclusion criteria and provide consent for the use of biopsy samples collected as part of standard clinical practice. The an...
Detailed Description
The primary objective of this project is to evaluate the prognostic role of the biomarker P53, as numerous studies suggest its association with poor prognosis. This analysis will be particularly relev...
Eligibility Criteria
Inclusion
- Patients aged \> 18 years
- Written informed consent approved by the competent Independent Ethics Committee
- Histopathological diagnosis of squamous cell carcinoma of the head and neck region originating from one of the following organs or structures: Oral cavity, oropharynx, larynx, hypopharynx
- Locally advanced stage: from T1N1M0 to T4N3M0
- Availability of a tissue sample from a biopsy performed according to clinical practice guidelines.
Exclusion
- Recurrent/metastatic disease
- Presence of a synchronous second tumor
Key Trial Info
Start Date :
May 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2032
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT06905145
Start Date
May 3 2024
End Date
May 1 2032
Last Update
April 1 2025
Active Locations (1)
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1
Istituto Nazionale Tumori | "Fondazione Pascale"
Napoli, Italy, 80131