Status:
RECRUITING
Guiding Opioid Administration by Nociception Level Index (NOL) in Patients With Regional Anesthesia
Lead Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Conditions:
Nociceptive Pain
Pain, Postoperative
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
General anesthesia consists of a combination of hypnotic drugs to achieve unconsciousness and opioid analgesics to ensure antinociception. An alternative approach to the intraoperative administration ...
Detailed Description
Modern general anesthesia aims to treat nociception induced by surgical stimulation while avoiding an overdose of opioid analgesics and reducing side effects of opioid administration. Underdosing of ...
Eligibility Criteria
Inclusion
- \- Patients undergoing elective trauma or orthopedic surgery with a combination of general and regional anesthesia
Exclusion
- Preexisting therapy with cardiac glycosides or pacemakers
- Cardiac arrhythmia (atrial fibrillation, atrioventricular block \> I°)
- Chronic opioid misuse
- Intraoperative treatment with ketamine, beta-adrenergic agonists, or clonidine
- Serious peripheral or cardiac autonomic neuropathy
- Inability to specify the postoperative pain level
- Postoperative treatment in an ICU
Key Trial Info
Start Date :
May 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT06905340
Start Date
May 12 2025
End Date
January 1 2026
Last Update
June 8 2025
Active Locations (1)
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1
Department of Anesthesiology; Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg Eppendorf
Hamburg, Germany, 20246