Status:
COMPLETED
Evaluation of Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
Lead Sponsor:
Ankara Medipol University
Collaborating Sponsors:
Istanbul Medipol University Hospital
Ankara University
Conditions:
Periodontitis
Inflammation
Eligibility:
All Genders
18-65 years
Brief Summary
Salivary and serum levels of TMAO and TNF-α can distinguish between individuals with periodontitis and periodontally healthy individuals.
Detailed Description
Trimethylamine N-oxide (TMAO), a gut flora-derived metabolite from dietary choline, has emerged as an indicator of atherosclerosis. Circulatory TMAO has been implicated in cardiovascular risks by alte...
Eligibility Criteria
Inclusion
- being over 18 and under 65 years of age;
- having at least 20 natural teeth excluding the third molars; and
- being systemically healthy.
Exclusion
- being smoker;
- chronic use of any systemic medication
- use of antibiotics and/or anti-inflammatory steroids, nonsteroidal anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, anticoagulants, or hormonal contraceptives within 3 months preceding the study;
- pregnancy or lactation; and
- use of orthodontic appliances
Key Trial Info
Start Date :
January 8 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 23 2024
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06906510
Start Date
January 8 2024
End Date
September 23 2024
Last Update
April 2 2025
Active Locations (1)
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1
İstanbul Medipol University, School of Dentistry
Istanbul, Fatih, Turkey (Türkiye), 34083