Status:
ENROLLING_BY_INVITATION
Polycolistin E Sodium Mesylate Combined With Intravenous Atomization for Carbapenem Resistant Gram-negative Bacteria in Pulmonary Infection
Lead Sponsor:
First Affiliated Hospital of Ningbo University
Conditions:
Lung Infection Bacterial
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Pulmonary infection is a kind of infectious disease that seriously damages human health. It usually starts quickly and progresses rapidly in clinical manifestations, and is often accompanied by upper ...
Eligibility Criteria
Inclusion
- Voluntarily participate in the study and sign the informed consent;
- Inpatients aged 18-80 years old, regardless of gender;
- Patients who met the diagnostic criteria for pulmonary infection in the Guidelines for the Diagnosis and Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia for Adults in China (2018 Edition);
- Infections caused by Gram-negative bacteria (CRO) that are known or strongly suspected to be resistant to carbapenems but sensitive to CMS.
Exclusion
- Age \> 80 years old;
- The patient had a history of severe allergy or hypersensitivity to polymyxins;
- Patients with serious dysfunction of heart, liver, kidney and other important organs;
- Patients with serious diseases such as malignant tumors and blood system diseases;
- Patients with low immune function and risk of opportunistic pathogen infection;
- Patients who used excessive colistin intravenous or atomized inhalation therapy within 72h before enrollment;
- Have participated in other clinical trials within three months;
- Pregnant or breastfeeding women;
- There are other circumstances that the researcher believes are not suitable for inclusion.
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06907069
Start Date
January 1 2025
End Date
December 31 2025
Last Update
April 2 2025
Active Locations (1)
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1
The First Affiliated Hospital of Ningbo University
Ningbo, Z, China, 315040