Status:
RECRUITING
Exploratory Biomarker Analysis of Neoadjuvant Chemoimmunotherapy Followed by Pulmonary Resection in Stage II-III Non-Small Cell Lung Cancer
Lead Sponsor:
Yonsei University
Conditions:
Clinical Stage II to III Non-Small Cell Lung Cancer
Eligibility:
All Genders
19+ years
Brief Summary
1. To explore tissue-based biomarkers to select patients who do not respond to neoadjuvant immunotherapy (non-responders) at the point of diagnosis 2. To explore blood-based non-invasive biomarkers to...
Detailed Description
1. Construction of a neoadjuvant chemoimmuntherapy cohort of resectable stage 2-3 lung cancer patients and acquisition of clinical-pathological-radiological data. 2. Plasma from individual patient wil...
Eligibility Criteria
Inclusion
- Histologically proven clinical stage II-III lung cancer patients
- No driver mutations (EGFR mutation and ALK alteration)
- Whole body performance (ECOG) 0-1
- Those over 19 years of age
- Subject who submitted Informed consent form
Exclusion
- Under 19 years of age
- If there is a history of causing infection or other serious medical problems that impair the patient's function and make it difficult to comply with the study protocol.
- Patients for whom the investigator determines that the patient should not participate in the clinical trial because the patient is judged to be unable to comply with the clinical trial procedures and requirements (a person lacking medical capacity)
- Other patients (pregnant women, etc.) determined by the clinical trial director to be unsuitable for this clinical trial.
Key Trial Info
Start Date :
August 7 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06907160
Start Date
August 7 2024
End Date
June 30 2029
Last Update
April 2 2025
Active Locations (1)
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1
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine
Seoul, South Korea