Status:
RECRUITING
Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Vaccination; Infection
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Immune response to influenza vaccine in patients with chronic renal insufficiency.
Detailed Description
Seasonal influenza vaccination is recommended for patients with chronic renal insufficiency, as influenza is responsible for significant morbidity and mortality in this immunocompromised population. H...
Eligibility Criteria
Inclusion
- Chronic renal failure patient at stage 4 or 5 (i.e. estimated GFR \< 30mL/min/1.73m2); or Dialysis patient; or renal transplant patient regardless of GFR;
- Age ≥ 18 years;
- Indication for influenza vaccination;
- Express free and informed consent.
Exclusion
- Known hypersensitivity to influenza vaccine or egg proteins;
- Previous influenza vaccination for the current season;
- Current infection;
- Current acute illness;
- Treatments with a major impact on vaccine response:
- Treatment of rejection within the previous 3 months;
- Renal transplantation with induction performed within the previous 6 months;
- Immunosuppressive treatment including CTLA4 agonist, complement inhibitor, anti-CD20;
- Treatments that may distort the serological response: Polyvalent immunoglobulin infusion within the preceding 3 months;
- Vulnerable persons (minors, adults under guardianship or trusteeship, persons deprived of their liberty, persons unable to speak French);
- Subjects not affiliated to Social Security.
Key Trial Info
Start Date :
September 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
735 Patients enrolled
Trial Details
Trial ID
NCT06907667
Start Date
September 3 2025
End Date
September 1 2026
Last Update
September 11 2025
Active Locations (1)
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1
CHU Nice - Hôpital Pasteur 2
Nice, Alpes-Maritimes, France, 06000