Status:
NOT_YET_RECRUITING
A Study Comparing Short-course Antifungal Therapy (SCAT) 7 Day vs Standard 14 Day Antifungal Therapy for Uncomplicated Candidemia
Lead Sponsor:
Augusta University
Conditions:
Candidemia
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this clinical trial is to assess whether a seven-day course of standard of care (echinocandin) antifungal therapy is non-inferior to a 14-day course of echinocandin antifungal therapy in p...
Eligibility Criteria
Inclusion
- Patients ≥ 18 years of age
- Uncomplicated candidemia (positive blood culture only). No evidence of invasive candidiasis at day 1 or until day 7.
- Received \< 5 days of prior antifungal therapy
- Informed Consent for randomization
- Patients that did not consent to randomization have consented to be used as a natural history (controls) and will allow collection of available data from the medical record.
Exclusion
- Inadequate source control (e.g., unable to remove endovascular devices, urinary catheters).
- Invasive candidiasis of any type (e.g., deep seated candidiasis from sources other than blood)
- Abnormal LFTs \> 10-fold
- Greater than 5 days of prior antifungal therapy
- Endovascular devices that cannot be removed.
- Immunocompromised patients (AIDS/HIV; solid organ transplant, bone marrow transplant patients, oncology patients receiving chemotherapy, neutropenic patients (ANC of \< 1,500 cells/L
- Neutropenic at time of consent (what does this mean)
- Break-through candidemia (people with prior candidemia who relapsed) after treatment with antifungal therapy)
- Unable to provide informed consent from either the patient or legally authorized authority (LAR)
- Expected mortality within 96 hours
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06907992
Start Date
May 1 2025
End Date
December 31 2027
Last Update
April 4 2025
Active Locations (1)
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1
Augusta University
Augusta, Georgia, United States, 30912