Status:
NOT_YET_RECRUITING
Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
HagaZiekenhuis
Maastricht University Medical Center
Conditions:
Deep Brain Stimulation
Parkinson Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease. The main ques...
Eligibility Criteria
Inclusion
- Diagnosis of idiopathic PD based on the UK Brain Bank criteria (Hughes et al. 1992);
- Age older than 18 years;
- Previous implantation of Medtronic PerceptTM PC/RC DBS electrodes bilateral targeting the STN;
- Reliable beta peak in at least one STN;
- Able to provide informed consent and comply with the study protocol;
- Understand the Dutch language.
Exclusion
- Legally incompetent adults;
- Patients with ongoing participation in other clinical trials involving neurological interventions;
- Inability to recognize the difference between the motor ON or OFF state;
- Mild cognitive impairment or dementia;
- Pregnancy.
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT06909045
Start Date
December 1 2025
End Date
December 1 2026
Last Update
September 15 2025
Active Locations (3)
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1
Amsterdam UMC
Amsterdam, Netherlands
2
Maastricht UMC+
Maastricht, Netherlands
3
HagaZiekenhuis
The Hague, Netherlands