Status:
RECRUITING
Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
Lead Sponsor:
Florida Atlantic University
Collaborating Sponsors:
Baptist Health South Florida
Conditions:
Laceration of Skin
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge ...
Eligibility Criteria
Inclusion
- Lacerations requiring one layer of sutures
- Lacerations appropriate for repair by emergency physicians
Exclusion
- Active bleeding from laceration
- Complex lacerations requiring multiple layers
- Lacerations to be repaired by a specialist service
- Patients with allergies to either diphenhydramine or lidocaine
- Laceration repairs would benefit from the use of epinephrine as an additive to the local anesthetic
Key Trial Info
Start Date :
September 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06910241
Start Date
September 3 2025
End Date
June 30 2028
Last Update
January 7 2026
Active Locations (1)
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1
Bethesda Hospital East
Boynton Beach, Florida, United States, 33435