Status:
COMPLETED
PRECOG Pilot Project
Lead Sponsor:
University of Reading
Collaborating Sponsors:
Biotechnology and Biological Sciences Research Council
Myota Limited
Conditions:
Cognition
Affect (Mental Function)
Eligibility:
All Genders
60-75 years
Phase:
NA
Brief Summary
This pilot study aims to investigate the chronic effects of a prebiotic blend on cognitive, affective and gut microbiome outcomes in healthy adults aged 60-75 years.
Detailed Description
This pilot study will employ a double-blind, randomised, placebo-controlled parallel design to investigate the chronic effects of 12-week-long prebiotic blend consumption on cognitive, affective, gut ...
Eligibility Criteria
Inclusion
- Aging between 60-75 years old
- Having normal vision and hearing
- Having a normal body mass index (BMI\<30)
Exclusion
- Having mild to moderate subjective cognitive complaints
- Smoking
- Having food allergies
- Following restrictive and/or unbalanced diets
- Changing dietary intake majorly in past month
- Being diagnosed with any psychiatric or neurologic conditions (e.g. schizophrenia, depression, dementia) including eating disorders
- Being diagnosed with any cardiometabolic diseases (including type II diabetes and cardiovascular disease), or suffering from hypertension or thrombosis related disorders or suffer from thyroid disease
- Currently taking anticoagulants, antiplatelet medication, antidepressants, proton-pump inhibitors
- Currently consuming prebiotic or probiotic supplements
- Continuous antibiotic use for \> 3 days within 1 month prior to enrolment
- Continuous use of weight-loss drug for \> 1 month before screening
- Having a significant gastrointestinal (GI) condition affecting absorption including (but not limited to) inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end stage renal disease; active cancer, or treatment for any cancer, in last 3 years
- Having a high fibre intake defined as \> 20g of fibre/day
- Wheat and/or gluten intolerance and having coeliac disease
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06911957
Start Date
May 1 2025
End Date
December 1 2025
Last Update
December 3 2025
Active Locations (1)
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1
University of Reading, School of Psychology and Clinical Languages
Reading, Berkshire, United Kingdom, RG6 6ES