Status:
COMPLETED
Efficacy of Diacerein Supplementation on Interleukin-1β, Hs-CRP, TNF-α Levels and Glycemic Control in Uncontrolled Type 2 Diabetes Mellitus Patients at Dr. Mohammad Hoesin General Hospital Palembang
Lead Sponsor:
Universitas Sriwijaya
Collaborating Sponsors:
Indonesia Endowment Fund for Education (LPDP), Ministry of Finance Republik of Indonesia
Conditions:
Uncontrolled Diabetes
Diabetes Mellitus Type 2
Eligibility:
All Genders
60-60 years
Phase:
PHASE2
PHASE3
Brief Summary
The goal of this clinical trial is to learn if diacerein supplementation can help improve inflammation and glycemic control in adults with uncontrolled type 2 diabetes. It will also study the safety a...
Detailed Description
The study aimed to evaluate the efficacy of diacerein supplementation compared to placebo towards interleukin-1β, hs-CRP, TNF-α levels and glycemic control in uncontrolled type 2 diabetes mellitus pat...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients diagnosed with uncontrolled type 2 diabetes mellitus who are receiving treatment at Dr. Mohammad Hoesin General Hospital, Palembang.
- Male and female patients aged 40-59 years.
- Willing to participate in the study by signing the informed consent form.
- Exclusion Criteria
- Pregnant or breastfeeding.
- History of allergy to medications containing rhein.
- Severe liver disorders.
- Chronic kidney disease.
- Malignancy.
- Currently receiving hormone replacement therapy.
- Autoimmune diseases.
- Severe bacterial infection.
- Osteoarthritis.
- Use of other anti-inflammatory drugs within the past 2 weeks.
- Drop-out Criteria
- Patients who discontinue medication for more than 2 weeks.
- Death.
- Occurrence of serious adverse drug reactions requiring discontinuation of the medication.
- Loss to follow-up.
Exclusion
Key Trial Info
Start Date :
June 21 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 8 2024
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT06912035
Start Date
June 21 2024
End Date
November 8 2024
Last Update
April 4 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Universitas Sriwijaya
Palembang, South Sumatera, Indonesia, 30126