Status:
RECRUITING
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
Lead Sponsor:
University of Ulm
Conditions:
Autonomic Function
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagoni...
Detailed Description
This research project aims to investigate to what extent the parasympathetic nervous system is responsible for the transmission of signals from the brain to peripheral organs. Furthermore, the study w...
Eligibility Criteria
Inclusion
- Age: at least 18
- BMI: 20 - 24.9 kg/m2 (for the healthy groups) or more than 28 kg/m2 (for the overweight groups)
- For women: Hormonal contraception with a single-phase preparation (e.g. Nuvaring)
- Understanding and voluntarily signing an informed consent form prior to study-related examinations
Exclusion
- Drug and/or alcohol abuse
- smoking
- Taking medication that affects blood sugar or addresses the central and/or autonomic nervous system (e.g. anti-epileptic drugs, beta blockers, dopamine agonists, antidepressants). Taking antihistamines.
- Pre-existing cardiac conditions
- Neurological pre-existing conditions
- Known cardiac arrhythmia
- Known allergies to ingredients, e.g. paracetamol and atropine
- Known narrow-angle glaucoma
- Known hyperthyroidism
- Known diseases of the urinary tract or prostate
- Pregnancy or breastfeeding
- At screening: Hb \< 12 g/dl for women and Hb \< 14 g/dl for men
- No consent to be informed about incidentally discovered pathological findings
- Any (clinical) condition which, in the opinion of the physician, could jeopardize the safety of the
- or would jeopardize the scientific success.
- Liver dysfunction
- Renal insufficiency
Key Trial Info
Start Date :
May 14 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT06912048
Start Date
May 14 2025
End Date
May 1 2027
Last Update
July 10 2025
Active Locations (1)
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1
Ulm University Hospital
Ulm, Germany, 89081