Status:
NOT_YET_RECRUITING
Feasibility Study to Compare Two Ventilatory Modes for Mechanical Ventilation Weaning
Lead Sponsor:
University of Lausanne Hospitals
Conditions:
Mechanical Ventilation Weaning
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
We hypothesize that the ventilatory mode Bilevel Positive Airway Pressure without any synchronization (BIPAPasynchro) may facilitate the weaning process of patients intubated with acute hypoxiemic res...
Detailed Description
Bilevel Positive Airway Pressure without any synchronization (BIPAPasynchro) ventilation is a ventilatory modality that guarantees a minimal mandatory minute ventilation, even in deeply sedated patien...
Eligibility Criteria
Inclusion
- Intubated ICU patient with acute respiratory failure;
- PaO2-FiO2 ratio of less than 300 mmHg (40 kPa) at least one hour after intubation;
- control or assist-control ventilation;
- expected duration of mechanical ventilation of more than 24 hours;
- clinician in charge considers that the patient can be switched to assisted ventilation (weaning phase start);
- informed consent obtained by the patient himself / legal representative or authorization received from independent physician
Exclusion
- less than 18 years old;
- pregnant women (because of very different respiratory mechanics);
- severe obesity (BMI \> 40 kg/m2);
- known obstructive pulmonary disease;
- expected death within one week or very poor prognosis with end-of-life care decision expected/treatment withdrawal;
- neurological disorders heavily influencing breathing pattern, like suspected or proven hypoxic brain injury, spinal injury above C8, severe traumatic brain injury, polyneuropathies (ex. Guillain-Barré, myasthenia gravis);
- home non-invasive ventilation prior to ICU admission, except CPAP for obstructive sleeping apnoea syndrome;
- tracheostomised at ICU admission;
- suspected or proven broncho-pleural fistulas;
- extracorporeal membrane oxygenation (ECMO) treatment;
- ICU admission for major burns;
- enrolment in other trial with competitive outcomes or treatment strategies;
- Known opposition to research participation if patient is not able to consent (eg patient with refused GC)
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 15 2027
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT06912906
Start Date
September 1 2025
End Date
April 15 2027
Last Update
April 15 2025
Active Locations (2)
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1
University Hospital of Lausanne
Lausanne, Canton of Vaud, Switzerland, 1011
2
Lausanne University Hospital (CHUV)
Lausanne, Switzerland