Status:
COMPLETED
Comparative Cardiovascular Effectiveness of GLP-1 RAs vs. Insulin in Early-Onset Type 2 Diabetes
Lead Sponsor:
Karolinska Institutet
Conditions:
Type 2 Diabetes Mellitus (T2DM)
Eligibility:
All Genders
18+ years
Brief Summary
The incidence of early-onset type 2 diabetes (T2D) is increasing globally. People with early-onset T2D have faster beta-cell deterioration and more aggressive diabetes progression than their late-onse...
Detailed Description
Yuxia Wei Introduction The incidence of T2D in adolescence and young adults is increasing alarmingly worldwide\[1\]. Early-onset (age at diagnosis \<40) T2D is more aggressive and has faster beta-cell...
Eligibility Criteria
Inclusion
- We will include people diagnosed with T2D for more than 6 months and with metformin use within 6 months before the initiation of the treatment of interest (GLP-1 RA or insulin).
Exclusion
- Individuals will be excluded if they meet one of the following criteria any time (unless stated otherwise) before or at treatment initiation: (1) other types of diabetes diagnosis recorded in NDR or NPR; (2) diagnosis of acute pancreatitis one month prior to treatment initiation; (3) diagnosis of other pancreatic diseases (chronic pancreatitis, cyst of pancreatis, etc; ICD-10 code K86) recorded in NPR; (4) use of GLP-1 RA or insulin within 1 year prior to treatment initiation, (5) advanced kidney disease (eGFR\<30 mL/min/1.73 m2, dialysis or kidney transplant \[procedure codes: KAS\[10\]\]); (6) end-stage liver disease (K70.4, K71.1, K72, Z94.4, procedure codes JJC); (7) cancer of the digestive system (ICD codes: C15-C26) or endocrine glands such as thyroid (ICD codes: C73-C75); (8) inflammatory bowel diseases (ICD-10 K50-K52)
Key Trial Info
Start Date :
January 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2025
Estimated Enrollment :
92100 Patients enrolled
Trial Details
Trial ID
NCT06913881
Start Date
January 1 2010
End Date
January 31 2025
Last Update
April 6 2025
Active Locations (1)
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1
Karolinska Institutet, Institute of Environmental Medicine
Stockholm, Sweden, 171 77