Status:
NOT_YET_RECRUITING
Esketamine Combined With PRF of DRG for Acute/Subacute Zoster-associated Pain
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
Beijing Xiaotangshan Hospital
The First Hospital of Fangshan District,Beijing
Conditions:
Herpes Zoster
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To assess the 1-month effects and safety of esketamine - PRF -standardized drug treatment against PRF -standardized drug treatment acute/subacute zoster-associated pain (ZAP) patients.
Detailed Description
This study aims to determine whether the addition of esketamine to PRF - standardized drug treatment can improve 1 - month pain control and safety profiles in acute/subacute ZAP patients. The findings...
Eligibility Criteria
Inclusion
- Ages more than 18 years;
- Patients with onset of herpes zoster (HZ) rash less than 90 days;
- HZ affected the spinal nerves (cervical/thoracic/lumbar nerve);
- Having an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10= worst possible pain)；
- Planned to perform CT-guided PRF treatment of the dorsal root ganglion(DRG).
Exclusion
- Obstructive sleep apnoea syndrome;
- Those who receive other more invasive treatments, such as radiofrequency thermocoagulation (RFT) of DRG.
- A history of systemic immune diseases, organ transplantation, or cancers;
- A history of severe cardiopulmonary, hepatic, renal dysfunction or coagulation function disorder;
- A history of schizophrenia, epilepsy, or myasthenia gravis, delirium;
- Comorbid hyperthyroidism or phaeochromocytoma;
- Recent history of drug abuse;
- Having contraindications to esketamine;
- Communication difficulties.
- Women who are preparing for pregnancy, in the pregnancy or lactation period.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
184 Patients enrolled
Trial Details
Trial ID
NCT06914206
Start Date
April 1 2025
End Date
July 1 2026
Last Update
April 9 2025
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070