Status:
NOT_YET_RECRUITING
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
Lead Sponsor:
Vienna Institute for Research in Ocular Surgery
Conditions:
Map Dot Fingerprint Dystrophy
Post-penetrating Keratoplasty
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy. This innovative method measures corneal elasticity by detecting s...
Eligibility Criteria
Inclusion
- Written informed consent prior to surgery
- Patients aged 18 years and older
- Patients who have undergone one of the following corneal surgeries or are diagnosed with one of the following dystrophies:
- Penetrating Keratoplasty (PKP) and no longer have sutures following PKP o Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)
- Descemet Membrane Endothelial Keratoplasty (DMEK)
- Fuchs' Endothelial Dystrophy (FED)
- Map Dot Fingerprint Dystrophy (MDFD)
- Healthy Controls: healthy eyes without any history of corneal diseases or surgeries
Exclusion
- Any of the following will exclude a subject from the study:
- Patients with inadequate corneal imaging or corneal scarring that would impact results
- Patients with other corneal dystrophies or corneal diseases
- Patients with active ocular infections or inflammatory conditions
- Patients unable to undergo Brillouin imaging adequately
- Patients that suffered an eye trauma according to their medical history
- Patients with fixational problems (e.g., head tremor) or with any medical condition that could interfere with the measurements
- Pregnancy (pregnancy test will be performed in women of reproductive age)
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06914817
Start Date
April 1 2025
End Date
October 1 2025
Last Update
April 6 2025
Active Locations (1)
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1
VIROS - a Karl Landsteiner Institute
Vienna, Austria, Austria, 1140