Status:
ENROLLING_BY_INVITATION
Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project
Lead Sponsor:
D'Or Institute for Research and Education
Conditions:
Colo-rectal Cancer
Polygenic Risk Score
Eligibility:
All Genders
18+ years
Brief Summary
Development of a polygenic risk score based on somatic and germline genetic information from patients with colorectal cancer
Detailed Description
Colorectal cancer (CRC) is the third most common cancer diagnosed in both men and women. Approximately 70% of CRC cases originate from spontaneous point mutations in oncogenes, tumor suppressor genes,...
Eligibility Criteria
Inclusion
- \> 18 years;
- Histologically confirmed diagnosis of colorectal cancer;
- Have available tumor material for somatic sequencing, obtained from biopsy or routine surgery;
- Sign the informed consent form (ICF) for the study.
Exclusion
- • Pregnants
Key Trial Info
Start Date :
March 14 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06917794
Start Date
March 14 2025
End Date
October 1 2027
Last Update
April 8 2025
Active Locations (9)
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1
Instituto D'Or de Pesquisa e Ensino
Fortaleza, Ceará, Brazil, 60135-237
2
CPOC - Centro de Pesquisa Oncológica e Clínica, faz parte do Complexo Associação Obras Sociais lrmã Dulce (AOSID)
Salvador, Estado de Bahia, Brazil, 40414-120
3
Instituto D'Or de Pesquisa e Ensino
Salvador, Estado de Bahia, Brazil, 40414-120
4
Instituto D'Or de Pesquisa e Ensino
Brasília, Federal District, Brazil, 70390-140