Status:
ENROLLING_BY_INVITATION
Psilocybin With Intracranial Neural Sensing
Lead Sponsor:
Joshua Woolley, MD, PhD
Conditions:
Chronic Pain
Eligibility:
All Genders
21-75 years
Phase:
PHASE1
Brief Summary
This is an open-label, single-arm, pilot study exploring the neural, sensory, and cognitive effects of a single, medium dose of psilocybin in patients with chronic pain who already have implanted sens...
Detailed Description
This is an open-label, single-arm, pilot study exploring the neural, sensory, and cognitive effects of a single, medium dose of psilocybin in patients with chronic pain who already have implanted sens...
Eligibility Criteria
Inclusion
- Currently implanted chronic brain sensing device (such as RC+S or Percept)
- Not currently enrolled in another trial
- Ability to speak and read English
- Able to attend all in-person and virtual visits
- No changes in medication or major surgical procedures anticipated for the trial
- Able to identify someone to accompany from the research unit at the end of drug administration day or agreement to have a study team member accompany them from the research unit
Exclusion
- A health condition that makes this study unsafe or unfeasible, determined by study physicians
- Use of medication, vitamins, or supplements and unwilling or unable to discontinue medications that have problematic interactions with psilocybin
- Adulthood epilepsy or other seizure disorder
- Require supplemental oxygen
- Medical finding or diagnosis that would make participation in this trial unsafe
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2028
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06919640
Start Date
June 1 2025
End Date
April 30 2028
Last Update
June 6 2025
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94143