Status:
ACTIVE_NOT_RECRUITING
Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery
Lead Sponsor:
The Second People's Hospital of Huai'an
Conditions:
Chronic Rhinosinusitis
Enhanced Recovery After Surgery
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
PHASE2
Brief Summary
Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of Functional endoscopic sinus surgery (FESS) is one of the effective ways to treat chronic sinusitis, w...
Detailed Description
The aim of this study was to investigate the effects of intravenous infusion of esketamine or magnesium sulphate on postoperative pain and quality of recovery in patients undergoing nasal endoscopic s...
Eligibility Criteria
Inclusion
- Age between 18 and 65 years
- American Society of Anesthesiologists (ASA) classification I-II
- Patients scheduled for FESS under general anaesthesia and with a procedure duration of not less than 30 minutes.
Exclusion
- Patients with hypersensitivity to esketamine, magnesium sulphate and other anaesthetic drugs;
- Combined vital organ insufficiency;
- Pregnant and lactating women;
- Those with a history of substance abuse;
- Patients who are unable to understand the study or who are mentally ill;
- Uncontrolled diabetes mellitus, hypertension, hyperthyroidism;
- Failure to understand or cooperate with HADS, SAS, SDS questionnaires, or the Pain Assessment Scale (VAS);
- Those who do not sign the informed consent form.
Key Trial Info
Start Date :
March 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2025
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT06920576
Start Date
March 1 2025
End Date
July 20 2025
Last Update
April 10 2025
Active Locations (1)
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1
The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second Hospital
Huaian, China