Status:
NOT_YET_RECRUITING
Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborating Sponsors:
University College Dublin
University of Stellenbosch
Conditions:
Syphilis, Congenital
Eligibility:
All Genders
Up to 7 years
Phase:
PHASE2
Brief Summary
CARES-1 is a randomised, open-label, phase II pharmacokinetic (PK) and safety study of ambulatory antibiotics for the treatment of neonates with "all-risk" asymptomatic congenital syphilis.
Eligibility Criteria
Inclusion
- Infants at risk of congenital syphilis at birth defined as:
- an infant born to a mother who tests positive for syphilis in pregnancy using registered and licensed locally-available diagnostic tests for example but not limited to a Treponemal rapid POCT, an RPR or both.
- AND
- the mother is untreated in the current pregnancy defined as:
- i. she tested positive at antenatal care and received no treatment OR ii. she was never tested during antenatal care OR iii. she tested negative at antenatal care and positive on re-testing at delivery
- OR c. the mother is inadequately treated in the current pregnancy defined as:
- i. Having received a non-penicillin based treatment regimen; and/or ii. Does not have documentation of 3 doses of IM Benzathine Penicillin, given 7-10 days apart, with the last dose given \> 30 days prior to delivery OR b. The mother was adequately treated in the current pregnancy BUT considers herself at risk of re-infection following a midwife delivered explanation of risk (partner treatment, multiple partners etc).
- Infants who are asymptomatic for a diagnosis of congenital syphilis following application of a clinical proforma by the study team (Appendix 1)
- Infants who are less than \<= 7 days of life AND with a post-menstrual age (PMA) of 34-42 weeks (Appendix 2).
- Infants who are tolerating enteral feeds, including if they are being administered by an NG tube.
Exclusion
- \- 1. The infant's clinical condition at birth or prior to randomisation requires ongoing (\> 48 hours) treatment with antibiotics with the potential for anti-treponemal activity i.e. B-lactams, Cephalosporins, Carbapenems.
- 2\. They have a birthweight \<2kg 3. They are nil by mouth. 4. They have a life-limiting congenital anomaly
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06921213
Start Date
October 1 2025
End Date
June 30 2027
Last Update
May 4 2025
Active Locations (3)
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1
Universitas Indonesia
Jakarta, Indonesia
2
Malawi Liverpool Wellcome Programme
Blantyre, Malawi
3
Stellenbosch
Stellenbosch, South Africa