Status:
NOT_YET_RECRUITING
Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation
Lead Sponsor:
Centre for Medical Sciences
Conditions:
Acute Hypoxemic Respiratory Failure
Mechanical Ventilation Complication
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The TEMA study (Targeting prEssure-Muscle-index to avoid ventilatory over-Assistance during pressure support ventilation) is a prospective, interventional crossover trial investigating the relationshi...
Detailed Description
The TEMA study is a prospective, interventional crossover trial designed to explore the physiological relationship between levels of pressure support (PS) and tidal volume (Vt) in mechanically ventila...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Mechanically ventilated in the ICU
- Diagnosis of Acute Hypoxemic Respiratory Failure (AHRF)
- Normocapnia or non-severe hypercapnia
- Receiving Pressure Support Ventilation (PSV) for at least 24-72 hours
- Presence of an arterial line for blood gas sampling
Exclusion
- Age \< 18 years
- Known neurological or neuromuscular disorders affecting diaphragm function
- Chronic Obstructive Pulmonary Disease (COPD) or hypercapnic respiratory failure
- Psychomotor agitation or inadequate sedation
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06921655
Start Date
June 1 2025
End Date
June 1 2027
Last Update
April 18 2025
Active Locations (1)
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1
Centre for Medical Sciences
Trento, Italy, 38122