Status:
NOT_YET_RECRUITING
Personalizing Adoptive Cell Transfer for Solid Tumors: Towards a New Patient-tailored Treatment Option
Lead Sponsor:
Ospedale San Raffaele
Collaborating Sponsors:
Fondazione Umberto Veronesi
Conditions:
Carcinoma, Non-Small-Cell Lung
Eligibility:
All Genders
18+ years
Brief Summary
This is a monocentric prospective observational study. This study will include patients with a diagnosis of non-small cell lung cancer for the collection of blood and tissue specimens.
Detailed Description
This study seeks to advance patient-specific cancer immunotherapy, through the ex-vivo generation of tumor-specific T cells recognizing and targeting tumor-specific mutations. The study will enroll 2...
Eligibility Criteria
Inclusion
- Participant is willing and able to provide informed consent for participation in the study.
- Age: Adults aged 18 years or older.
- Diagnosis: non-small cell lung cancer (Stage I-II, III), with or without lymph node involvement, ideally with sufficient tumor burden to provide adequate tissue for analysis. In accordance with good clinical practice, patients with early-stage disease will undergo direct surgery, whereas patients with advanced-stage disease will receive neoadjuvant treatment followed by surgery.
- Ability to attend scheduled follow-up visits, if applicable, for additional peripheral blood sample collection during treatment.
Exclusion
- Presence of any active infection or underlying condition that could compromise the safety of tissue and blood sampling.
- Prior history of another malignancy that might interfere with data interpretation related to non-small cell lung cancer progression and immune response.
- Any current use of immunosuppressive medications (e.g., high-dose steroids) which might alter immune response assessments, except as part of non-small cell lung cancer treatment.
- Pregnancy and breastfeeding
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2029
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06922266
Start Date
May 1 2025
End Date
April 30 2029
Last Update
April 10 2025
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