Status:
RECRUITING
Hemadsorption to Enhance Drug Elimination in Intoxications
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Intoxication by Drug
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with pro...
Detailed Description
In this prospective interventional study with medical device, the investigotors would include 18 patients admitted to ICU after an intoxication with a quantifiable neurodepressing drugs (type benzodia...
Eligibility Criteria
Inclusion
- older than18 years
- Admission to ICU
- GCS \< 8 or requiring Flumazenil 8 hours after hospital admission
- Having an intoxication with a benzodiazepine or tricyclic antidepressant that we can measure/quantify
- Having a risk factor for delayed drug elimination defined as either Cirrhosis CHILD B/C or chronic kidney insufficiency KDIGO 3b or worse
Exclusion
- Pregnant patient
- Patients in chronic dialysis before admission
- Need for mechanical ventilation for other reasons than intoxications (e.g. pneumonia, neurotrauma)
- Concomitant pathology requiring continued intravenous sedation
- Known history of seizures
- Contra-indication to heparin use
- DNR restricting the use of mechanical ventilation or dialysis
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2029
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT06922786
Start Date
May 1 2025
End Date
January 1 2029
Last Update
May 15 2025
Active Locations (1)
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1
Universitair Ziekenhuis Brussel
Brussels, Brussels Capital, Belgium, 1090