Status:
RECRUITING
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
Lead Sponsor:
Centre Hospitalier Régional d'Orléans
Conditions:
Weaning Invasive Mechanical Ventilation
Weaning-induced Pulmonary Edema
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at ...
Eligibility Criteria
Inclusion
- Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial
- Richmond Agitation Sedation Scale (RASS) between -1 and +1
- Patient at high risk of re-intubation with at least one of the following criteria:
- Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)
- Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity/hypoventilation syndrome, restrictive lung disease)
Exclusion
- Neuromuscular pathology (myasthenia type) preceding hospitalization
- Pregnant or breast-feeding women
- Patient already included in the study
- Protected person (under guardianship or curatorship)
- Person under court protection
- Person not affiliated to a social security scheme
Key Trial Info
Start Date :
April 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06923267
Start Date
April 30 2025
End Date
May 1 2026
Last Update
May 15 2025
Active Locations (1)
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1
Chu Orleans
Orléans, France, 45067