Status:
RECRUITING
Evaluating the Preliminary Efficacy and Safety of JS207 in NSCLC After Progression Following Platinum-based Chemotherapy and Immunotherapy
Lead Sponsor:
Shanghai Junshi Bioscience Co., Ltd.
Conditions:
Advanced NSCLC
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
This is a multiple-arm, open phase II clinical trial evaluating the safety, tolerability,and preliminary efficacy of JS207 in NSCLC after progression following Platinum-based chemotherapy and immunoth...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed locally advanced (stage IIIB/IIIC) NSCLC that is not amenable to radical surgery or radical radiochemotherapy, or Metastatic or recurrent NSCLC.
- Subjects with unresectable locally advanced or metastatic or recurrent NSCLC who have failed first-line treatment with PD-1/PD-L1 inhibitors combined with platinum-based doublet chemotherapy (excluding docetaxel); or who have failed sequential first- and second-line treatment with PD-1/PD-L1 inhibitors followed by platinum-based doublet chemotherapy (excluding docetaxel).
- Subjects must have at least one measurable lesion according to RECIST v1.1.
Exclusion
- Histopathologically or cytopathologically confirmed to have combined neuroendocrine component.
- Sensitivity mutation of EGFR or ALK fusion.
- Tumor encircles important blood vessels or has obvious necrosis and air space, and the investigator considers that it may cause hemorrhage risk.
Key Trial Info
Start Date :
July 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 26 2026
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT06924606
Start Date
July 15 2025
End Date
June 26 2026
Last Update
December 31 2025
Active Locations (18)
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1
Beijing Chest Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 101100
2
Jilin Cancer Hospital
Jilin, Changchun, China, 130012
3
Hunan Cancer Hospital
Hunan, Changsha, China, 410031
4
West China Hospital, Sichuan University
Sichuan, Chengdu, China, 610044