Status:
COMPLETED
Study of of Oxygen Nebulized Inhalation EGCG in Cancer Patients With New Coronary Pneumonia
Lead Sponsor:
Shandong Cancer Hospital and Institute
Conditions:
Pneumonia, Interstitial
Cancer Patients
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions, such as anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic eff...
Detailed Description
The Phase II study was conducted with a randomized, controlled, placebo dose determined by Phase I. the subjects were divided into two groups (experimental group and placebo group). To observe the eff...
Eligibility Criteria
Inclusion
- Diagnosed malignant tumors by pathology or cytology
- COVID-19 with a confirmed positive polymerase chain reaction or antigen test result for SARS-CoV-23
- moderate-to-severe COVID-19 pneumonia (defined as any radiographic evidence of pulmonary infiltrates and oxygen saturation \>94% on room air)
- Pulmonary function of the patient can be treated with aerosol inhalation for 7 days
Exclusion
- Current or recent progresses rapidly and may develop into a Critical illness with coronavirus in a short period of time
- Caused by other viruses such as cytomegalovirus, as well as pneumocystis pneumonia, pulmonary edema, aspiration pneumonia and acute interstitial pneumonia
- Any condition including medical, emotional, psychiatric, or logistical that, in the opinion of the Investigator would preclude the participant from adhering to the protocol or would increase the risk associated with study participation
- known allergy or hypersensitivity to EGCG
Key Trial Info
Start Date :
June 5 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 2 2024
Estimated Enrollment :
111 Patients enrolled
Trial Details
Trial ID
NCT06924749
Start Date
June 5 2023
End Date
July 2 2024
Last Update
November 28 2025
Active Locations (2)
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1
Shan Dong cancer hospital and institute
Jinan, Shandong, China, 250117
2
Hanxi Zhao
Jinan, Shandong, China, Shandong Cancer Hospital