Status:
ACTIVE_NOT_RECRUITING
Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Poisoning
Toxicokinetics
Eligibility:
All Genders
18-85 years
Brief Summary
The goal of this observational study is to establish a predictive model for the clinical use value of fat emulsion as an antidote based on the physical information of fat emulsion on drug diffusion pr...
Eligibility Criteria
Inclusion
- Patients with a clear history of acute drug exposure;
- The exposed drug is a lipid soluble drug (with a lipid water distribution coefficient logP\>0);
- Age: 18-85 years old;
- The patient or guardian agrees to participate in this project and signs an informed consent form;
Exclusion
- Patients with shock and severe lipid metabolism disorders (such as hyperlipidemia);
- Patients with unclear exposure history;
- Drug exposure time \> 24 hours;
- Exposure to two or more drugs;
- Select patients with specific detoxifying agents;
- Merge patients with severe cardiovascular and cerebrovascular diseases;
- Patients with negative blood toxicity test results or overdose of non-fat-soluble drugs;
- Those who fail to provide complete general information and clinical data;
Key Trial Info
Start Date :
June 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT06926439
Start Date
June 1 2024
End Date
May 31 2027
Last Update
April 13 2025
Active Locations (1)
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1
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China, 210008