Status:
RECRUITING
Postoperative Radiotherapy in Breast Cancer- Concurrent or Sequential With Chemotherapy
Lead Sponsor:
Dr. Tabassum Wadasadawala
Conditions:
Invasive Breast Cancer
Stage III Breast Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This clinical research aims to determine if concurrent chemotherapy and radiation therapy is more effective than sequential chemotherapy and radiation therapy for patients with stage IIB-III breast ca...
Eligibility Criteria
Inclusion
- Pathologically confirmed invasive breast cancer
- Stage IIB-III invasive breast cancer (AJCC 8th edition)
- Patients planned for adjuvant chemotherapy and adjuvant radiotherapy
- Patients fit to receive adjuvant chemotherapy and radiotherapy
- Age \> 18 years
Exclusion
- Hypersensitivity to taxanes
- Patients receiving entire chemotherapy prior to surgery (neoadjuvant setting)
- Unable or unwilling for regular follow up
- Bilateral tumour needed RT to both sides
- Patients planned for RT to oligometastatic sites
- Unfavourable anatomical factors potentially leading to higher radiotherapy dose to heart and/or lungs (Exceeding the protocol specific mandatory dose constraints).
- Pregnant patient
Key Trial Info
Start Date :
May 14 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2031
Estimated Enrollment :
858 Patients enrolled
Trial Details
Trial ID
NCT06926543
Start Date
May 14 2024
End Date
May 1 2031
Last Update
April 13 2025
Active Locations (5)
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1
Homi Bhabha Cancer Hospital & Research Centre
Vishkhapatnam, Andhra Pradesh, India, 530053
2
Tata Memorial Centre
Mumbai, Maharasthra, India, 400012
3
Homi Bhabha Cancer Hospital and Research Centre
New Chandigarh, Punjab, India, 140901
4
Homi Bhabha Cancer Hospital, Sangrur
Sangrur, Punjab, India, 148001