Status:

RECRUITING

The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial

Lead Sponsor:

The Gut Microbiome Center (Centar za crijevni mikrobiom)

Collaborating Sponsors:

Clinical Hospital Centre Zagreb

Conditions:

Endometriosis

Probiotics

Eligibility:

FEMALE

Up to 35 years

Phase:

NA

Brief Summary

ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to ...

Detailed Description

Patients will be recruited among the outpatient population of the National Center for Endometriosis, Department of Gynecological Surgery and Urology, Gynecology Department, University Hospital Center ...

Eligibility Criteria

Inclusion

  • Minimum Age: - Maximum Age: 35 Years Sex: Female Gender Based: Ye - only women can participate in this study Accepts Healthy Volunteers: No
  • adult subjects with stage III or IV endometriosis diagnosis confirmed by biopsy

Exclusion

  • Age \> 35 years
  • Immunocompromised patients
  • Patients with chronic inflammatory diseases (e.g., autoimmune disorders)
  • Pregnancy
  • Use of supplements and foods with probiotics
  • Use of immunosuppressant, antibiotic, proton pump inhibitors and corticosteroid drugs
  • Use of probiotics product less than one month before start of study or during study

Key Trial Info

Start Date :

November 1 2024

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

November 30 2025

Estimated Enrollment :

40 Patients enrolled

Trial Details

Trial ID

NCT06929364

Start Date

November 1 2024

End Date

November 30 2025

Last Update

April 16 2025

Active Locations (1)

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University Hospital Center Zagreb

Zagreb, Croatia, 10000