Status:
NOT_YET_RECRUITING
Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotics and Steroids?
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Chronic Obstructive Pulmonary Disease
COPD
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to see if the use of two simple blood tests: C reactive protein and eosinophils, can reduce the use of steroids and antibiotics in patients with flares of chronic ob...
Detailed Description
Study design: randomized, controlled, feasibility trial Population: Adult patients with a physician diagnosis of COPD suffering from an acute exacerbation of COPD Intervention: Recommendations for a...
Eligibility Criteria
Inclusion
- Outpatients with a known diagnosis of COPD (must have prior spirometry documenting FEV1/FVC post-bronchodilator \< 0.7 or documented respirologist-diagnosis of COPD)
- Presenting with AECOPD, defined as an increase in respiratory symptoms necessitating an increase in medications
- Consent provided
Exclusion
- An individual who meets any of the following criteria will be excluded from participation in this study:
- new infiltrate on chest x-ray day of randomization
- temperature ≥ 38.0 ◦C taken orally day of randomization
- positive blood culture day of randomization
- co-morbid asthma or severe bronchiectasis
- acute heart failure day of randomization
- known immunosuppression including the use of chronic glucocorticoids day of randomization
- allergy/absolute contraindication to the use of oral steroids
- planned pregnancy or currently pregnant
- COVID positive
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06929767
Start Date
September 1 2025
End Date
October 1 2026
Last Update
April 16 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6