Status:
RECRUITING
Organoid Models of Hepatocellular Carcinoma
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Hepatocellular Carcinoma
Organoids
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns an...
Detailed Description
The objectives of the project will be 1) to develop HCC PDOs from tumour and non-tumour patient liver tissue obtained from surgical specimens or liver biopsies; 2) to evaluate genomic and transcriptom...
Eligibility Criteria
Inclusion
- Capacity to express informed consent;
- Age ≥18 years;
- Suspected radiological diagnosis of HCC or diagnosis of HCC with indications for surgical resection.
Exclusion
- Age \< 18 years;
- Contraindications to liver biopsy (ascites, platelets\<50,000, INR\>1.7);
- Contraindications to HCC resection surgery;
- Active viral infection;
- Refusal to sign informed consent to participate in the study.
Key Trial Info
Start Date :
October 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06929845
Start Date
October 1 2024
End Date
August 31 2026
Last Update
September 15 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC CEMAD, Largo A. Gemelli, 8
Roma, Italy, 00168