Status:
COMPLETED
Vasopressin in the Elderly: Physiological Changes in Neuroendocrine Function and Urinary Secretion in Healthy Aging
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Healthy Ageing
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Elderly people are at a high risk for disturbances in water homeostasis, with both hypo- and hypernatremia being more common with increasing age. Several changes in the physiology of the ageing body a...
Eligibility Criteria
Inclusion
- Age 18-30 years or ≥ 60 years
- Normonatremia (135-145 mmol/L)
- Plasma osmolality 280-300 mOsm/kg
- BMI ≥18 and ≤ 30 kg/m2
Exclusion
- Regular use of medication with effects on water homeostasis (e.g. blood pressure medication, neuroleptics, desmopressin, etc.)
- Any severe disease requiring frequent medical care, except physiotherapy and/or psychotherapy
- Pacemaker or ICD
- History of thrombosis
- Active oncologic disease
- Heart failure
- Liver cirrhosis
- Estimated glomerular filtration rate (eGFR) \< 60 ml/kg/1.73 m2
- Uncontrolled hypertension \>160 mmHg systolic or \>100 mmHg diastolic
- Polydipsia (ingestion of \>3L fluids per day) and polyuria (\>50 ml/kg urine production within 24 hours)
- Pregnancy or breastfeeding
- Participation in a study with investigational drugs within 30 days
- Acute illness
- Inability to follow study procedures
Key Trial Info
Start Date :
April 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 10 2025
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT06930300
Start Date
April 30 2025
End Date
October 10 2025
Last Update
November 25 2025
Active Locations (1)
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1
University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031