Status:
RECRUITING
Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Conditions:
Postpartum Hemorrhage (Primary)
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony. Carbetocin, a long acting analog of o...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- non-laboring women with gestational age between 37 to 41 weeks
- not exposed to exogenous oxytocin, scheduled for a primary or first repeat cesarean delivery under neuraxial anesthesia.
- Exclusion criteria:
- patients requiring general anesthesia
- more than 1 previous cesarean delivery
- history of uterine atony
- emergency cesarean section in labor
- patients using medications that could affect myometrial contractility such as nifedipine, labetalol, or magnesium sulphate.
- patients with any condition of predisposing to uterine atony and postpartum hemorrhage, such as abnormal placentation, multiple gestation, severe preeclampsia, macrosomia, polyhydroamnios, large uterine fibroids, chorioamnionitis, previous history of postpartum bleeding.
Exclusion
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06930391
Start Date
September 15 2025
End Date
June 1 2026
Last Update
September 24 2025
Active Locations (1)
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1
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G1X5