Status:
COMPLETED
IL-1β and S1P Levels After Periodontal Therapy: A Split-Mouth Study
Lead Sponsor:
Ondokuz Mayıs University
Conditions:
Sphingosine 1-phosphate
Interleukin 1-beta
Eligibility:
All Genders
45-60 years
Phase:
NA
Brief Summary
This randomized split-mouth clinical trial aimed to evaluate the changes in interleukin-1 beta (IL-1β) and sphingosine-1-phosphate (S1P) levels in gingival crevicular fluid (GCF) following non-surgica...
Detailed Description
Diseased sites were selected based on the most severe clinical findings, including probing depth (PD) of ≥6 mm, clinical attachment level (CAL) of ≥5 mm, and the presence of bleeding on probing (BOP)....
Eligibility Criteria
Inclusion
- Aged between 45 and 60 years
- Systemically healthy individuals with no known systemic conditions
- Non-smokers or former smokers who had quit at least two years prior
- Diagnosed with Stage III periodontitis according to the 2017 World Workshop Classification
- Presence of at least three diseased sites with probing depth (PD) ≥ 6 mm, clinical attachment level (CAL) ≥ 5 mm, and bleeding on probing (BOP \[+\])
- Presence of at least three periodontally healthy sites with PD ≤ 3 mm, no CAL, and no BOP
- No periodontal treatment within the last 6 months
- Provided written informed consent
Exclusion
- Presence of systemic diseases known to affect periodontal status (e.g., diabetes mellitus, cardiovascular disease, autoimmune disorders)
- Use of antibiotics or anti-inflammatory medications within the last 6 months
- History of periodontal surgery within the past 12 months
- Pregnant or lactating women
- Current smokers or individuals who quit less than two years ago
- Sites with endodontic lesions, caries extending to the cervical area, trauma-related gingival recession, or bone loss due to non-periodontal causes
- Undergoing orthodontic treatment during the study period
Key Trial Info
Start Date :
May 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 10 2024
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT06930430
Start Date
May 15 2023
End Date
September 10 2024
Last Update
April 16 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Periodontology, Faculty of Dentistry, Ondokuz Mayis University
Samsun, Atakum, Turkey (Türkiye), 55200