Status:
NOT_YET_RECRUITING
Aprepitant in the Management of Immune Checkpoint Inhibitors Pruritus in Solid Cancer Patients
Lead Sponsor:
Rabin Medical Center
Conditions:
Pruritus
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Pruritus, commonly known as itching, is an unpleasant sensation that triggers the urge to scratch, which may provide temporary relief. Pruritus can be intermittent or persistent, localized or widespre...
Eligibility Criteria
Inclusion
- Age ≥18 years.
- Histologically confirmed solid tumor (e.g., melanoma, RCC, NSCLC).
- Currently receiving ICIs (such as but not limited to nivolumab, pembrolizumab, ipilimumab)
- Pruritus that is either:
- Refractory: Persistent pruritus despite standard treatment (e.g., antihistamines, corticosteroids).
- New-onset: Developing after initiation of ICIs or targeted therapies.
- ECOG performance status 0-2.
- Willingness to comply with study procedures and provide informed consent.
Exclusion
- History of severe allergic reactions to Aprepitant.
- Uncontrolled or severe dermatologic conditions unrelated to cancer therapy.
- Use of NK1R antagonists within 4 weeks before study entry.
- Concurrent use of medications that strongly interact with Aprepitant.
- Concurrent use of medications that may influence pruritus manifestation (e.g steroids or antihistamines) . Note, Regular treatment with such medications prior to the appearance of pruritus, and or pruritus appearing despite such regular treatment, will not disqualify you from participating in the study
- Uncontrolled infection or significant comorbidities.
- Pregnant or breastfeeding women.
Key Trial Info
Start Date :
May 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06931119
Start Date
May 30 2025
End Date
December 30 2026
Last Update
April 17 2025
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.