Status:
COMPLETED
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
Lead Sponsor:
Saglik Bilimleri Universitesi
Collaborating Sponsors:
Health Institutes of Turkey
Conditions:
Type 2 Diabetes Mellitus (T2DM)
Necrotic Pulp
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (...
Detailed Description
Systemic diseases such as Type 2 Diabetes Mellitus (T2DM) are known to influence both the etiology and healing process of endodontic diseases. T2DM is characterized by chronic hyperglycemia and impair...
Eligibility Criteria
Inclusion
- • Individuals aged between 18 and 65 years
- Voluntarily agree to participate in the study and attend follow-up sessions
- Systemically healthy individuals (no systemic diseases)
- Not taking antihypertensive or antidiabetic medications
- Not pregnant
- No use of corticosteroids or antibiotics within the last 3 months
- No history of smoking
- No acute pain or extraoral swelling
- No sinus tract or acute apical abscess
- Presence of a periapical lesion with a Periapical Index (PAI) score ≥ 3
- Presence of a mature, single-rooted permanent tooth with completed root development
Exclusion
- • Severe periodontal disease
- Internal or external root resorption
- Open apex (immature root development)
- Suspected vertical root fracture
- Non-restorable teeth
- Teeth with previous root canal treatment
- Presence of developmental dental anomalies
Key Trial Info
Start Date :
October 21 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 7 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06931678
Start Date
October 21 2024
End Date
April 7 2025
Last Update
April 17 2025
Active Locations (1)
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1
Gulhane Faculty of Dentistry, University of Health Sciences
Ankara, Etlik, Turkey (Türkiye), 06010